This day/night rhythm in firing rate is the main signal the SCN sends to the rest of the brain to communicate the time of day. pumilio's SCN neurons spontaneously fired at a higher rate during daytime hours than at night. The team found that like nocturnal rodents, R. pumilio's SCN neurons behave that have never been observed before in nocturnal species." "We've also found unique features in how R. pumilio is similar to the pattern previously observed in night-active species," said Beatriz Bano-Otalora, co-first author of the paper and a biologist working with the labs of Robert Lucas and Timothy Brown at the University of Manchester. "We found that the overall day/night pattern of SCN neuron activity in the diurnal rodent R. "This work is the first to describe the intricate electrical landscape of the SCN in a diurnal mammal, and it's highlighted notable differences from nocturnal animals that may be important in adapting clock neuron function to the specific biological demands of a day-active species." "Almost everything we know about the brain's circadian clock comes from studies on night-active rodents such as rats and mice, which complicates translating this knowledge to human circadian rhythms," said Casey Diekman, co-corresponding author of the study and mathematical biologist at New Jersey Institute of Technology. Researchers say the study is an advance toward more precisely exploring the connection between circadian rhythms and human health, including the relationship between daytime light exposure and circadian clock-related sleep disorders. Until now, brain recording studies of nocturnal species have primarily been used to form an understanding of the mammalian master circadian clock - located in the brain's hypothalamic suprachiasmatic nucleus (SCN), where nearly 20,000 neurons synchronize with the light-dark cycle via electrical signals to orchestrate circadian rhythms in our physiology and behavior. 30 in the journal eLife, researchers have reported the first-ever recording and modeling of the electrical activity of circadian clock neurons in a diurnal species - the four-striped grass mouse, Rhabdomys pumilio.
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